Análisis de la Incidencia de Formación de Valores en la Disciplina Escolar en la asignatura de Lengua y Literatura en los estudiantes de Undécimo Grado “Centro Escolar Estrella de Belén”, municipio El Cua, departamento de Jinotega, II Semestre 2015

Esta investigación, persigue como objetivo analizar la incidencia de la formación de valores en la disciplina escolar de los estudiantes de 11mo grado, Centro Escolar Estrella de Belén, municipio El Cua-Jinotega, durante el segundo semestre 2015. En este sentido se determinó , a través de entrevistas, encuestas y registros de observación la percepción de estudiantes, docentes y directores del centro, sobre el comportamiento escolar en el ámbito disciplinario. Los resultados obtenidos en esta investigación, evidencian la disciplina escolar que se practica en el centro y los valores trasmitidos por los padres de familia a sus hijos, los caules se pueden convertir en directrices para la revisión de los procesos de gestión por parte de la dirección y del ejercicio docente. Lo anterior permite proponer estrategias, y con ello mejorar la formación de valores en el Centro Escolar. Palabras Claves: Disciplina Escolar, Valores, Comportamient

Spatially Resolved Gene Expression Prediction from H&E Histology Images via Bi-modal Contrastive Learning

Histology imaging is an important tool in medical diagnosis and research, enabling the examination of tissue structure and composition at the microscopic level. Understanding the underlying molecular mechanisms of tissue architecture is critical in uncovering disease mechanisms and developing effective treatments. Gene expression profiling provides insight into the molecular processes underlying tissue architecture, but the process can be time-consuming and expensive. In this study, we present BLEEP (Bi-modaL Embedding for Expression Prediction), a bi-modal embedding framework capable of generating spatially resolved gene expression profiles of whole-slide Hematoxylin and eosin (H&E) stained histology images. BLEEP uses a contrastive learning framework to construct a low-dimensional joint embedding space from a reference dataset using paired image and expression profiles at micrometer resolution. With this framework, the gene expression of any query image patch can be imputed using the expression profiles from the reference dataset. We demonstrate BLEEP's effectiveness in gene expression prediction by benchmarking its performance on a human liver tissue dataset captured via the 10x Visium platform, where it achieves significant improvements over existing methods. Our results demonstrate the potential of BLEEP to provide insights into the molecular mechanisms underlying tissue architecture, with important implications in diagnosis and research of various diseases. The proposed framework can significantly reduce the time and cost associated with gene expression profiling, opening up new avenues for high-throughput analysis of histology images for both research and clinical applications

Evidence for active maintenance of inverted repeat structures identified by a comparative genomic approach

Inverted repeats have been found to occur in both prokaryotic and eukaryotic genomes. Usually they are short and some have important functions in various biological processes. However, long inverted repeats are rare and can cause genome instability. Analyses of C. elegans genome identified long, nearly-perfect inverted repeat sequences involving both divergently and convergently oriented homologous gene pairs and complete intergenic sequences. Comparisons with the orthologous regions from the genomes of C. briggsae and C. remanei show that the inverted repeat structures are often far more conserved than the sequences. This observation implies that there is an active mechanism for maintaining the inverted repeat nature of the sequences

Analysis of Semi-Rigid Connections Subject to Fire Loads in a Steel Framework

The purpose of this study is to develop an approach that considers fire as a load in the design of structures. Recent studies of the full-scale fire tests in Cardington, UK and the World Trade Centre collapse have shown that the behaviour of steel structures in fire when assembled into a frame differs from that measured or predicted by fire testing of individual structural elements, revealing the importance of accounting for realistic fire loads in the design of structures and the potential inadequacy of fire testing individual elements as employed by current building codes. Yet, there has been limited basic research and development to allow consideration of fire as a load in the analysis and design of structures. In response to this much needed work, this thesis develops an approach to include fire as a load in the analysis of a 2-bay by 2-storey structure when a semi-rigid connection is exposed to thermal loads typical of those that might be encountered during a real fire. The structural fire analysis is principally based on incorporating moment-rotation-temperature data for the connection, as found in archival literature, into a structural analysis software package developed at the University of Waterloo. The software employs a modified Displacement Method for analyzing structures, which involves the computation of stiffness reduction factors that represent the deterioration of strength of the structural elements as they are subjected to various loads. By modifying the moment-rotation-temperature data for a semi-rigid connection into a form recognized by the software, a fire load is simulated by incrementally elevating the temperature of the affected steel connection. In this way, a fragility analysis of the entire structure under fire load is conducted. A series of example calculations are presented for cases in which the semi-rigid connection is exposed to increasing temperatures of 20°C, 200°C, 400°C and 600°C. The analysis showed that as the connection is heated, it is weakened, and the steel structure undergoes a redistribution of moments from the heated connection to other non-heated elements within the framework, which is essentially a form of fire-resistance of the assembled structure that unassembled members in isolation do not have. The study also demonstrated that the experimental moment-rotation-temperature data reported in archival literature can be incorporated into the structural analysis, and that additional force-deformation data obtained from further experimental work or through finite-element analyses would allow the study to be extended to analyze the effects of fire loading on other structural elements of an assembled framework. To demonstrate the link between the predicted structural response at different temperatures and the development of a compartment fire, a fire modelling analysis is also performed

Dipstick proteinuria is an independent predictor of high on treatment platelet reactivity in patients on clopidogrel, but not aspirin, admitted for major adverse cardiovascular events.

Abstract The effectiveness of aspirin and clopidogrel in patients with chronic kidney disease (CKD) suffering from acute cardiovascular events is unclear. High on treatment platelet reactivity (HTPR) has been associated with worse outcomes. Here, we assessed the association of dipstick proteinuria (DP) and renal function on HTPR and clinical outcomes. Retrospective cohort analysis of 261 consecutive, non-dialysis patients admitted for Major Adverse Cardiovascular Events (MACE) that had VerifyNow P2Y12 and VerifyNow Aspirin assays performed. HTPR was defined as P2Y12 reactivity unit (PRU) \u3e 208 for clopidogrel and aspirin reaction units (ARU) \u3e 550 for aspirin. Renal function was classified based on the estimated glomerular filtration rate (eGFR), and dipstick proteinuria was defined as ≥30 mg/dl of albumin detected on a spot analysis. All cause mortality, readmissions, and cardiac catheterizations were reviewed over 520 days. In patients on clopidogrel (n = 106), DP was associated with HTPR, independent of eGFR, diabetes mellitus, smoking or use of proton pump inhibitor (AOR = 4.76, p = 0.03). In patients with acute coronary syndromes, HTPR was associated with more cardiac catheterizations (p = 0.009) and readmissions (p = 0.032), but no differences in in-stent thrombosis or re-stenosis were noted in this cohort. In patients on aspirin (n = 155), no associations were seen between DP and HTPR. However, all cause mortality was significantly higher with HTPR in this group (p = 0.038). In this cohort, DP is an independent predictor of HTPR in patients on clopidogrel, but not aspirin, admitted to the hospital for MACE

Diagnostic accuracy and predictive value in differentiating the severity of dengue infection

Objective: To review the diagnostic test accuracy and predictive value of statistical models in differentiating the severity of dengue infection. Methods: Electronic searches were conducted in the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, MEDLINE (complete), PubMed and Scopus. Eligible studies to be included in this review were cohort studies with participants confirmed by laboratory test for dengue infection and comparison among the different severity of dengue infection by using statistical models. The methodological quality of the paper was assessed by independent reviewers using QUADAS-2. Results: Twenty-six studies published from 1994 to 2017 were included. Most diagnostic models produced an accuracy of 75% to 80% except one with 86%. Two models predicting severe dengue according to the WHO 2009 classification have 86% accuracy. Both of these logistic regression models were applied during the first three days of illness, and their sensitivity and specificity were 91-100% and 79.3-86%, respectively. Another model which evaluated the 30-day mortality of dengue infection had an accuracy of 98.5%. Conclusion: Although there are several potential predictive or diagnostic models for dengue infection, their limitations could affect their validity. It is recommended that these models be revalidated in other clinical settings and their methods be improved and standardised in future

Telescope Alignment From Sparsely Sampled Wavefront Measurements Over Pupil Subapertures

Alignment of two-element telescopes is a classic problem. During recent integration and test of the Space Interferometry Mission s (SIM s) Astrometric Beam Combiner (ABC), the innovators were faced with aligning two such telescope subsystems in the presence of a further complication: only two small subapertures in each telescope s pupil were accessible for measuring the wavefront with a Fizeau interferometer. This meant that the familiar aberrations that might be interpreted to infer system misalignments could be viewed only over small sub-regions of the pupil, making them hard to recognize. Further, there was no contiguous surface of the pupil connecting these two subapertures, so relative phase piston information was lost; the underlying full-aperture aberrations therefore had an additional degree of ambiguity. The solution presented here is to recognize that, in the absence of phase piston, the Zygo measurements primarily provide phase tilt in the subaperture windows of interest. Because these windows are small and situated far from the center of the (inaccessible) unobscured full aperture, any aberrations that are higher-order than tilt will be extremely high-order on the full aperture, and so not necessary or helpful to the alignment. Knowledge of the telescope s optical prescription allows straightforward evaluation of sensitivities (subap mode strength per unit full-aperture aberration), and these can be used in a predictive matrix approach to move with assurance to an aligned state. The technique is novel in every operational way compared to the standard approach of alignment based on full-aperture aberrations or searching for best rms wavefront. This approach is closely grounded in the observable quantities most appropriate to the problem. It is also more intuitive than inverting full phase maps (or subaperture Zernike spectra) with a ray-tracing program, which must certainly work in principle, but in practice met with limited success. Even if such classical alignment techniques became practical, the techniques reported here form a reassuringly transparent and intuitive check on the course of the alignment with very little computational effort